Tissue Tropism of a H5N1 Highly Pathogenic Avian Influenza Virus in Naturally Infected Domestic Breeder Ducks during 2006/2007 Epidemic in South Korea ( 07/06/27 ) | |||||
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Part | Charger | mckim00 | date | 07/06/27 | |
Poster presentation in the Korean Society of Veterinary Science on April 20, 2007.
Results and conclusion
Results:
All breeder ducks infected with HPAI virus showed clinical signs with depression, decreased egg production and feed consumption. The common gross lesions were diarrhea, hepatomegaly, splenomegaly, paintbrush hemorrhage on the
surface of liver, petechial hemorrhage on the adipose tissue and pericardium, marginal hemorrhage in pancreas, white
stripe on cardiac muscle, and severe hemorrhagic and misshapen egg. Histopathologic lesions were seen in the brain,
liver, lung, airsac, heart, spleen, pancreas, ovary and oviduct. These lesions consisted mainly of meningencephalitis,
cardiac myocyte necrosis, splenic lymphocytes necrosis and hyperplasia, mild interstitial pneumonia, severe enteritis,
moderate hepatic necrosis, lipidosis, severe pancreatic vacuolation, and acina epithelial necrosis. We observed the
inflammation in theca interna and medullary interstitium of ovary and necrosis of oviduct epithelium as the same layer
hens. Immunohistochemically, we infrequently detected the viral antigen in the digestive respiratory but detected
widespread it in the reproductive organs of the breeder ducks. Occasionally, the viral antigen of one duck exception
distributed vascular endothelium in most organs even at the neuronal cells in the brain.
Conclusion:
We commonly know HPAI viruses replicate to a limited degree. However, we noticed the virus can spread systemically via the vascular and neuronal systems in domestic ducks. We infer the clinical signs and death are dependent upon
other factors including concurrent infections, acquired immunity, conditional status and other environmental factors.
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